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UniProtKB - P0DTB8 (SCX38_CENMA)
Protein
Toxin Cm38
Gene
N/A
Organism
Centruroides margaritatus (Central American bark Scorpion)
Status
Functioni
May block sodium channels (Nav) found (By similarity).
Reversibly modifies the firing of DRG neurons by causing membrane depolarization and increasing the number of action potentials (PubMed:25633390).
Shows antimicrobial activity against the Gram-negative bacteria K.pneumoniae (MIC=64 µM), and only a very weak activity against S.aureus (PubMed:25633390).
Does not show hemolytic activity (PubMed:25633390).
By similarity1 PublicationGO - Molecular functioni
- sodium channel inhibitor activity Source: InterPro
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- defense response to bacterium Source: UniProtKB-KW
Keywordsi
Molecular function | Antibiotic, Antimicrobial, Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Toxin Cm381 Publication |
Organismi | Centruroides margaritatus (Central American bark Scorpion) |
Taxonomic identifieri | 29018 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Centruroides |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000449319 | 1 – ›19 | Toxin Cm38Add BLAST | ›19 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 12 ↔ ? | Curated | ||
Disulfide bondi | 16 ↔ ? | Curated |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.1 Publication
Structurei
3D structure databases
AlphaFoldDBi | P0DTB8 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Sequence similaritiesi
Family and domain databases
InterProi | View protein in InterPro IPR044062, LCN-type_CS_alpha_beta_dom IPR002061, Scorpion_toxinL/defensin |
Pfami | View protein in Pfam PF00537, Toxin_3, 1 hit |
i Sequence
Sequence statusi: Fragment.
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 19 | 1 |
Mass spectrometryi
Molecular mass is 6800.31 Da. Determined by MALDI. 1 Publication
Cross-referencesi
Web resourcesi
The antimicrobial peptide database |
3D structure databases
AlphaFoldDBi | P0DTB8 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family and domain databases
InterProi | View protein in InterPro IPR044062, LCN-type_CS_alpha_beta_dom IPR002061, Scorpion_toxinL/defensin |
Pfami | View protein in Pfam PF00537, Toxin_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SCX38_CENMA | |
Accessioni | P0DTB8Primary (citable) accession number: P0DTB8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 22, 2020 |
Last sequence update: | April 22, 2020 | |
Last modified: | May 25, 2022 | |
This is version 5 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families